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The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study

Authors

  • Ville Karhunen Research Unit of Mathematical Sciences, University of Oulu, Oulu, Finland Research Unit of Population Health, University of Oulu, Oulu, Finland Department of Epidemiology and Biostatistics, Imperial College London, London, UK PubMed articlesGoogle scholar articles
  • Dipender Gill Department of Epidemiology and Biostatistics, Imperial College London, London, UK PubMed articlesGoogle scholar articles
  • Jian Huang Department of Epidemiology and Biostatistics, Imperial College London, London, UK Singapore Institute for Clinical Sciences (SICS), Agency for Science Technology and Research (A*STAR), Singapore PubMed articlesGoogle scholar articles
  • Emmanouil Bouras Department of Hygiene and Epidemiology, Faculty of Medicine, University of Ioannina, Ioannina, Epirus, Greece PubMed articlesGoogle scholar articles
  • Rainer Malik Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Faculty of Medicine, Munchen, Bayern, Germany PubMed articlesGoogle scholar articles
  • Mark J Ponsford Division of Immunology, Infection, and Inflammation, Tenovus Institute, Cardiff University, Cardiff, UK PubMed articlesGoogle scholar articles
  • Ari Ahola-Olli The Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland PubMed articlesGoogle scholar articles
  • Areti Papadopoulou Department of Hygiene and Epidemiology, Faculty of Medicine, University of Ioannina, Ioannina, Epirus, Greece PubMed articlesGoogle scholar articles
  • Saranya Palaniswamy Research Unit of Population Health, University of Oulu, Oulu, Finland PubMed articlesGoogle scholar articles
  • Sylvain Sebert Research Unit of Population Health, University of Oulu, Oulu, Finland PubMed articlesGoogle scholar articles
  • Matthias Wielscher Department of Epidemiology and Biostatistics, Imperial College London, London, UK Department of Dermatology, Medical University of Vienna, Vienna, Austria PubMed articlesGoogle scholar articles
  • Juha Auvinen Research Unit of Population Health, University of Oulu, Oulu, Finland PubMed articlesGoogle scholar articles
  • Juha Veijola Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Oulu, Finland PubMed articlesGoogle scholar articles
  • Karl-Heinz Herzig Research Unit of Biomedicine, Medical Research Center (MRC), University of Oulu, University Hospital, Oulu, Finland Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland PubMed articlesGoogle scholar articles
  • Markku Timonen Research Unit of Population Health, University of Oulu, Oulu, Finland Unit of Primary Care, Oulu University Hospital, Oulu, Finland PubMed articlesGoogle scholar articles
  • Sirkka Keinänen-Kiukaanniemi Research Unit of Population Health, University of Oulu, Oulu, Finland Unit of Primary Care, Oulu University Hospital, Oulu, Finland Healthcare and Social Services of Selänne, Pyhäjärvi, Finland PubMed articlesGoogle scholar articles
  • Martin Dichgans Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Faculty of Medicine, Munchen, Bayern, Germany Munich Cluster for Systems Neurology (SyNergy), Munich, Germany German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany PubMed articlesGoogle scholar articles
  • Marko Salmi MediCity and Institute of Biomedicine, University of Turku, Turku, Finland PubMed articlesGoogle scholar articles
  • Sirpa Jalkanen MediCity and Institute of Biomedicine, University of Turku, Turku, Finland PubMed articlesGoogle scholar articles
  • Terho Lehtimäki Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland PubMed articlesGoogle scholar articles
  • Veikko Salomaa Finnish Institute for Health and Welfare, Helsinki, Uusimaa, Finland PubMed articlesGoogle scholar articles
  • Olli Raitakari Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland PubMed articlesGoogle scholar articles
  • Simon A Jones Division of Immunology, Infection, and Inflammation, Tenovus Institute, Cardiff University, Cardiff, UK PubMed articlesGoogle scholar articles
  • G Kees Hovingh Department of Vascular Medicine, Academic Medical Center, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Noord-Holland, Netherlands PubMed articlesGoogle scholar articles
  • Konstantinos K Tsilidis Department of Epidemiology and Biostatistics, Imperial College London, London, UK Department of Hygiene and Epidemiology, Faculty of Medicine, University of Ioannina, Ioannina, Epirus, Greece PubMed articlesGoogle scholar articles
  • Marjo-Riitta Järvelin Research Unit of Population Health, University of Oulu, Oulu, Finland Department of Epidemiology and Biostatistics, Imperial College London, London, UK Unit of Primary Care, Oulu University Hospital, Oulu, Finland MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK Biocenter Oulu, University of Oulu, Oulu, Finland Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK PubMed articlesGoogle scholar articles
  • Abbas Dehghan Department of Epidemiology and Biostatistics, Imperial College London, London, UK MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK UK Dementia Research Institute, Imperial College London, London, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Ville Karhunen, Research Unit of Population Health, Oulun yliopisto, Oulu, Finland; ville.karhunen{at}oulu.fi
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Citation

Karhunen V, Gill D, Huang J, et al
The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study
BMJ Medicine 2023;2:e000157. doi: 10.1136/bmjmed-2022-000157

Publication history

  • Received February 7, 2022
  • Accepted November 25, 2022
  • First published February 14, 2023.
Online issue publication 
February 14, 2023
Review history

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.