RT Journal Article
SR Electronic
T1 Role of precision medicine in obstructive sleep apnoea
JF BMJ Medicine
JO bmjmed
FD BMJ Publishing Group Ltd
SP e000218
DO 10.1136/bmjmed-2022-000218
VO 2
IS 1
A1 Yu Liu
A1 Ali Abdul Ghafoor
A1 Mohammadreza Hajipour
A1 Najib Ayas
YR 2023
UL http://bmjmedicine.bmj.com/content/2/1/e000218.abstract
AB Obstructive sleep apnoea is a substantial clinical and public health problem because it contributes to harmful effects on quality of life, daytime symptoms, road traffic incidents, and cardiometabolic disease. Increasingly, obstructive sleep apnoea is recognised as a heterogeneous disease, and patients have varied susceptibility to long term complications and different responses to treatment. This narrative review summarises the current knowledge of precision medicine in obstructive sleep apnoea, particularly the role of symptom clusters, polysomnogram phenotypes, physiological endotypes, and circulating biomarkers in defining subtypes. In the near future, the prognostic accuracy of these measures in predicting long term complications in obstructive sleep apnoea will likely be improved, together with better matching of treatments to disease subtypes.