Table 3

Models for the log odds ratio (standard error); (95% credible interval) for screen failure examining variation in estimates (expressed as standard deviations) for between trial, between condition and between trial and condition by coefficient

ModelBetween trialBetween conditionBetween treatment
Intercept:
Trial0.29 (0.04); (0.23 to 0.39)
Trial and condition0.28 (0.04); (0.21 to 0.38)0.11 (0.08); (0.01 to 0.31)
Trial, condition, and treatment0.19 (0.06); (0.10 to 0.32)0.10 (0.08); (0.00 to 0.32)0.22 (0.09); (0.03 to 0.39)
Age (decades):
Trial0.04 (0.01); (0.03 to 0.05)
Trial and condition0.03 (0.01); (0.02 to 0.05)0.02 (0.01); (0.00 to 0.04)
Trial, condition, and treatment0.02 (0.01); (0.01 to 0.04)0.01 (0.01); (0.00 to 0.04)0.03 (0.01); (0.00 to 0.05)
Male sex:
Trial0.07 (0.01); (0.05 to 0.10)
Trial and condition0.06 (0.01); (0.04 to 0.09)0.05 (0.03); (0.01 to 0.13)
Trial, condition, and treatment0.05 (0.02); (0.02 to 0.08)0.05 (0.03); (0.00 to 0.14)0.03 (0.02); (0.00 to 0.09)
Comorbidity count:
Trial0.07 (0.01); (0.05 to 0.09)
Trial and condition0.07 (0.01); (0.05 to 0.09)0.02 (0.02); (0.00 to 0.06)
Trial, condition, and treatment0.04 (0.02); (0.02 to 0.07)0.03 (0.02); (0.00 to 0.08)0.05 (0.02); (0.00 to 0.10)
Asian race/ethnic group:
Trial0.07 (0.02); (0.04 to 0.11)
Trial and condition0.07 (0.02); (0.04 to 0.11)0.04 (0.03); (0.00 to 0.12)
Trial, condition, and treatment0.04 (0.03); (0.00 to 0.10)0.04 (0.03); (0.00 to 0.13)0.06 (0.03); (0.01 to 0.13)
Black race/ethnic group:
Trial0.08 (0.02); (0.04 to 0.12)
Trial and condition0.08 (0.02); (0.04 to 0.13)0.04 (0.03); (0.00 to 0.12)
Trial, condition, and treatment0.06 (0.03); (0.01 to 0.12)0.04 (0.03); (0.00 to 0.12)0.05 (0.03); (0.00 to 0.13)
Indigenous race/ethnic group:
Trial0.11 (0.05); (0.04 to 0.22)
Trial and condition0.11 (0.05); (0.05 to 0.23)0.08 (0.09); (0.00 to 0.31)
Trial, condition, and treatment0.08 (0.06); (0.00 to 0.22)0.09 (0.09); (0.00 to 0.32)0.09 (0.06); (0.00 to 0.25)
Other race/ethnic group:
Trial0.16 (0.04); (0.09 to 0.24)
Trial and condition0.14 (0.04); (0.08 to 0.23)0.08 (0.07); (0.00 to 0.24)
Trial, condition, and treatment0.11 (0.05); (0.04 to 0.21)0.07 (0.07); (0.00 to 0.25)0.11 (0.06); (0.01 to 0.24)
  • Models were conducted at three levels: trial (where condition and treatment were ignored); trial nested within condition; and trial nested within condition and treatment. See online supplemental appendix for full description of models.