Overview of serious adverse events for deep brain stimulation with antiparkinsonian drug treatment versus antiparkinsonian drug treatment only, occurring in more than one patient
| Trial | Deep brain stimulation with antiparkinsonian drugs | Antiparkinsonian drugs | ||
| No and type of serious adverse events | Proportion with serious adverse event | No and type of serious adverse events | Proportion with serious adverse event | |
| Blomstedt 201835 | — | 1/9 | — | 0/10 |
| Deuschl 200634 | 3 deaths, 3 worsening of mobility, 2 infections | 10/78 | — | 3/78 |
| Schuepbach 201339 | 39 events related to Parkinson's disease, 12 life threatening events, 10 other events related to surgery or device, 6 depression, 5 worsening of mobility, 4 other related to drugs or stimulation, 4 dislocation of device, 4 impaired wound healing, 3 injuries, 2 reoperation to repair device, 2 intracerebral abscess or oedema, 2 suicide attempts, 2 suicides | 68/124 | 31 events related to Parkinson's disease, 11 worsening of mobility, 9 life threatening events, 6 psychosis or hallucinations, 7 motor fluctuations, 5 other related to drugs or stimulation, 5 impulse control disorders, 2 dyskinesia, 2 anxiety, 2 suicide attempts, 2 cardiac disorders | 56/127 |
| Schüpbach 200736 | — | 0/10 | — | 0/10 |
| Williams 201038 | 19 other events, 16 infections, 11 worsening of symptoms of Parkinson's disease or uncontrolled symptoms of Parkinson's disease, 5 postoperative confusion, 4 urinary retention, 4 haemorrhage, 3 neuropsychiatric disturbances (including hallucinations or paranoia), 3 constipation, 3 falls, 2 neck pain, 2 seizure, 2 pulmonary embolism, 2 Parkinson's disease related and drug related, 2 deaths | 65/183 | 18 other events, 7 falls, 2 worsening of symptoms of Parkinson's disease or uncontrolled symptoms of Parkinson's disease, 2 constipation, 2 Parkinson's disease related and drug related | 26/183 |
| Weaver 200937 | 15 nervous system disorders, 12 infection at the stimulation site, 6 falls, 4 glioma, lung neoplasm malignant, or prostate cancer, 3 confusional state, 2 mental status change, 2 anaemia, 2 medical device complication, 2 procedural complications, 2 cerebrovascular accident, 2 angioplasty, bone graft, or transurethral prostatectomy, 2 dyskinesia, 2 deaths | 49/121 | 3 nervous system disorders, 2 falls | 15/134 |
| Charles 201440 | — | 2/15 | — | 0/14 |