Table 2

Summary of findings for network meta-analysis comparing use tocilizumab and sarilumab for covid-19, alone or in combination with corticosteroids

ComparisonOdds ratio (95% CrI)Risk difference (95% CrI)Certainty/quality of evidenceSummary
Intervention 1
(No of deaths/1000 people)
Intervention 2
(No of deaths/1000 people)
Tocilizumab v standard care1.12 (0.91 to 1.38)150 per 1000130 per 1000Low (risk of bias, imprecision)Tocilizumab might increase or reduce mortality compared with standard care
Difference: 19.73 more per 1000 (−15.78 to 58.52)
Sarilumab v standard care1.07
(0.81 to 1.40)
141 per 1000130 per 1000Low (risk of bias, imprecision)Sarilumab might increase or reduce mortality compared with standard care.
Difference: 10.60 more per 1000 (−38.37 to 55.17)
Corticosteroids v standard care0.84
(0.75 to 0.93)
101 per 1000130 per 1000Moderate (risk of bias)Corticosteroids probably reduce mortality compared with standard care
Difference: 29.27 fewer per 1000 (−46.74 to −12.24)
Sarilumab v tocilizumab0.95
(0.68 to 1.35)
141 per 1000150 per 1000Very low (risk of bias, imprecision)The effects of sarilumab compared with tocilizumab are uncertain
Difference: 9.13 fewer per 1000
(−74.66 to 49.13)
Tocilizumab and corticosteroids v corticosteroids alone0.79
(0.70 to 0.88)
66 per 1000101 per 1000Moderate (risk of bias)Tocilizumab, in combination with corticosteroids, probably reduces mortality compared with corticosteroids alone
Difference: 34.54 fewer per 1000 (−51.80 to −18.23)
Sarilumab and corticosteroids v corticosteroids alone0.73 (0.58 to 0.92)58 per 1000101 per 1000Low (risk of bias, imprecision)Sarilumab, in combination with corticosteroids, might reduce mortality compared with corticosteroids alone
Difference: 42.73 fewer per 1000 (−72.61 to −12.00)
Tocilizumab and corticosteroids v sarilumab and corticosteroids1.07
(0.86 to 1.34)
66 per 100058 per 1000Low (risk of bias, imprecision)Tocilizumab, in combination with corticosteroids, could have similar effects to reduce mortality compared with sarilumab in combination with corticosteroids
Difference: 8.19 more per 1000
(−20.49 to 34.96)