Table 1

SARS-CoV-2 variants and related spike protein mutations

WHO nomenclature or designationPango lineageSpike protein mutations of interestFirst detected samples*
Variants of concern
AlphaB.1.1.7N501Y. D614G, P681HUK, September 2020
BetaB.1.351N501Y. D614G, E484K, K417N, A701VSouth Africa, May 2020
GammaP.1N501Y, D614G, E484K, K417T, H655YBrazil, November 2020
DeltaB.1.617.2L452R, D614G, P681R, T478KIndia, October 2020
OmicronB.1.1.529N501Y, D614G, E484A, P681H, K417N, H655Y, A67V, Δ69-70, T95I, G142D, Δ143-145, N211I, Δ212, ins215EPE, G339D, S371L, S373P, S375F, N440K, G446S, S477N, T478K, Q493R, G496S, Q498R, Y505H, T547K, N679K, N764K, D796Y, N856K, Q954H, N969K, L981FSouth Africa and Botswana, November 2021
Variants of interest
LambdaC.37L452Q, D614G, F490SPeru, December 2020
MuB.1.621N501Y, D614G, P681H, R346K, E484KColumbia, January 2021
Variants under monitoring
Not assignedB.1.1.318D614G, P681H, E484KMultiple countries, January 2021
Not assignedC.1.2N501Y, D614G, E484K, H655Y, N679K, Y449HSouth Africa, May 2021
Not assignedB.1.640N501Y, D614G, P681H, F490R, N394S, R346S, Y449N, 137-145delMultiple countries, September 2021

  • Information correct as of 24 January 2022.

  • *First detection worldwide.