Effect of regular allopurinol dispensing, serum urate, and colchicine dispensing on adjusted hazard ratios for time to fatal or first non-fatal cardiovascular event within five years in study population, according to sex and analysis model. Data are adjusted hazard ratio (95% confidence interval)
| Predictor | Women | Men | ||||
| Model 2 | Model 3 | Model 4 | Model 2 | Model 3 | Model 4 | |
| Regular allopurinol dispensing * | ||||||
| Non-gout | 0.75 (0.67 to 0.83) | — | — | 0.91 (0.85 to 0.97) | — | — |
| Gout (dispensed) | 1 | — | — | 1 | — | — |
| Gout (not dispensed) | 0.99 (0.85 to 1.15) | — | — | 1.15 (1.05 to 1.25) | — | — |
| Serum urate levels | ||||||
| Non-gout | — | 0.73 (0.63 to 0.85) | — | — | 0.95 (0.85 to 1.05) | — |
| Gout (<0.36 mmol/L) | — | 1 | — | — | 1 | — |
| Gout (≥0.36 mmol/L) | — | 0.99 (0.83 to 1.20) | — | — | 1.16 (1.04 to 1.30) | — |
| Gout (unmonitored) | — | 0.93 (0.76 to 1.15) | — | — | 1.11 (0.98 to 1.25) | — |
| Colchicine dispensing † | ||||||
| Non-gout | — | — | 0.67 (0.58 to 0.78) | — | — | 0.75 (0.69 to 0.81) |
| Gout (dispensed) | — | — | 1 | — | — | 1 |
| Gout (not dispensed) | — | — | 0.87 (0.74 to 1.03) | — | — | 0.84 (0.77 to 0.92) |
Model 2=Cox proportional hazards model for fatal or first non-fatal cardiovascular events adjusted for age; ethnic origin; level of deprivation; history of diabetes; admission to hospital for atrial fibrillation; and dispensing of blood pressure lowering, lipid lowering, antiplatelet, or anticoagulant drug treatments; plus the additional variable of defined gout categorised by those individuals who were dispensed regular allopurinol and those who were not dispensed regular allopurinol. Model 3=Cox proportional hazards model for fatal or first non-fatal cardiovascular events adjusted for age; ethnic origin; level of deprivation; history of diabetes; admission to hospital for atrial fibrillation; and dispensing of blood pressure lowering, lipid lowering, antiplatelet; or anticoagulant drug treatments; plus the additional variable of those individuals with defined gout categorised by those who had a recent serum urate <0.36 mmol/L,≥0.36 mmol/L, or did not have serum urate testing in the previous three years. Model 4=Cox proportional hazards model for fatal or first non-fatal cardiovascular events adjusted for age; ethnic origin; level of deprivation; history of diabetes; admission to hospital for atrial fibrillation; and dispensing of blood pressure lowering, lipid lowering, antiplatelet, or anticoagulant drug treatments; plus the additional variable of defined gout categorised by those individuals who were dispensed colchicine at least once in the previous 12 months compared with those who were not dispensed colchicine.
*Allopurinol dispensed in at least three of four quarters of 2012.
†Colchicine dispensed at least once in the 12 months before 1 January 2012.