Table 2

Odds ratios for association between trial attrition and age, sex, and comorbidity count for different models

Model‡Comorbidity count*Age†Sex†
NoOdds ratio (95% CrI)Bayesian P valueNoOdds ratio (95% CrI)Bayesian P valueNoOdds ratio (95% CrI)Bayesian P value
Pooled (ignoring drug class and index condition)n=89 trials1.11 (1.07 to 1.14)1.00n=90 trials1.04 (0.98 to 1.11)0.89n=83 trials0.99 (0.93 to 1.05)0.32
SD trial0.100.220.13
Partial pooling across index conditionsn=20 index conditions1.11 (1.06 to 1.15)1.00n=20 index conditions1.06 (0.97 to 1.20)0.89n=18 index conditions0.99 (0.90 to 1.11)0.41
SD trial0.090.210.11
SD index condition0.050.090.12
Partial pooling across drug classesn=17 drug classes1.09 (1.05 to 1.15)1.00n=17 drug classes1.04 (0.97 to 1.13)0.86n=17 drug classes1.00 (0.92 to 1.11)0.50
SD trial0.100.220.09
SD drug class0.040.070.11
Partial pooling across index conditions and drug classn=20 index conditions; n=17 drug classes1.11 (1.05 to 1.15)1.00n=20 index conditions; n=17 drug classes1.05 (0.96 to 1.16)0.89n=18 index conditions; n=17 drug classes1.00 (0.90 to 1.12)0.49
SD trial0.090.210.09
SD index condition0.040.090.09
SD drug class0.040.070.09
  • CrI=credible interval; SD=standard deviation.

  • *Trial level models adjusted for age, sex, and comorbidity count.

  • †Trial level models adjusted for age and sex. Bayesian P value to describe proportion of distribution above odds ratio of 1. See online supplemental appendix for full description of models.

  • ‡Standard deviation for variation within groups for trials, index conditions, and drug classes on log-odds scale.