Table 2

Odds ratios for association between trial attrition and age, sex, and comorbidity count for different models

Model‡	Comorbidity count*			Age†			Sex†
Model‡	No	Odds ratio (95% CrI)	Bayesian P value	No	Odds ratio (95% CrI)	Bayesian P value	No	Odds ratio (95% CrI)	Bayesian P value
Pooled (ignoring drug class and index condition)	n=89 trials	1.11 (1.07 to 1.14)	1.00	n=90 trials	1.04 (0.98 to 1.11)	0.89	n=83 trials	0.99 (0.93 to 1.05)	0.32
SD trial	0.10	—	—	0.22	—	—	0.13	—	—
Partial pooling across index conditions	n=20 index conditions	1.11 (1.06 to 1.15)	1.00	n=20 index conditions	1.06 (0.97 to 1.20)	0.89	n=18 index conditions	0.99 (0.90 to 1.11)	0.41
SD trial	0.09	—	—	0.21	—	—	0.11	—	—
SD index condition	0.05	—	—	0.09	—	—	0.12	—	—
Partial pooling across drug classes	n=17 drug classes	1.09 (1.05 to 1.15)	1.00	n=17 drug classes	1.04 (0.97 to 1.13)	0.86	n=17 drug classes	1.00 (0.92 to 1.11)	0.50
SD trial	0.10	—	—	0.22	—	—	0.09	—	—
SD drug class	0.04	—	—	0.07	—	—	0.11	—	—
Partial pooling across index conditions and drug class	n=20 index conditions; n=17 drug classes	1.11 (1.05 to 1.15)	1.00	n=20 index conditions; n=17 drug classes	1.05 (0.96 to 1.16)	0.89	n=18 index conditions; n=17 drug classes	1.00 (0.90 to 1.12)	0.49
SD trial	0.09	—	—	0.21	—	—	0.09	—	—
SD index condition	0.04	—	—	0.09	—	—	0.09	—	—
SD drug class	0.04	—	—	0.07	—	—	0.09	—	—

CrI=credible interval; SD=standard deviation.
*Trial level models adjusted for age, sex, and comorbidity count.
†Trial level models adjusted for age and sex. Bayesian P value to describe proportion of distribution above odds ratio of 1. See online supplemental appendix for full description of models.
‡Standard deviation for variation within groups for trials, index conditions, and drug classes on log-odds scale.