Week 12 | Week 18 | Week 26 | Week 52 | All | |
HbA1c | |||||
Mean (95% CI) difference | −0.6 (−0.72 to −0.49) | −0.62 (−0.73 to −0.5) | −0.6 (−0.72 to −0.49) | −0.59 (−0.71 to −0.46) | — |
τ2 | 0.02 | 0.03 | 0.02 | 0.03 | — |
First centile | −0.75 | −0.77 | −0.75 | −0.74 | −0.75 |
99th centile | −0.5 | −0.51 | −0.5 | −0.46 | −0.48 |
Median | −0.61 | −0.62 | −0.61 | −0.59 | −0.6 |
Interquartile range | 0.06 | 0.08 | 0.06 | 0.08 | 0.07 |
Major adverse cardiovascular events | |||||
Hazard ratio (95% CI) | 0.58 (0.4 to 0.85) | 0.67 (0.5 to 0.9) | 0.72 (0.55 to 0.93) | 0.75 (0.61 to 0.92) | — |
τ2 | 0 | 0 | 0 | 0 | — |
First centile | 0.17 | 0.2 | 0.22 | 0.23 | 0.20 |
99th centile | 0.96 | 0.89 | 0.95 | 0.81 | 0.89 |
Median | 0.58 | 0.61 | 0.66 | 0.72 | 0.62 |
Interquartile range | 0.16 | 0.2 | 0.21 | 0.23 | 0.22 |
Serious adverse events | |||||
Hazard ratio (95% CI) | 0.78 (0.66 to 0.92) | 0.87 (0.77 to 0.98) | 0.87 (0.79 to 0.96) | 0.91 (0.86 to 0.96) | — |
τ2 | 0 | 0 | 0 | 0 | — |
First centile | 0.49 | 0.65 | 0.67 | 0.66 | 0.59 |
99th centile | 1.16 | 1.2 | 1.06 | 0.97 | 1.14 |
Median | 0.78 | 0.87 | 0.87 | 0.9 | 0.87 |
Interquartile range | 0.09 | 0.04 | 0.04 | 0.04 | 0.09 |
Serious adverse events without major adverse cardiovascular events | |||||
Hazard ratio (95% CI) | 0.84 (0.66 to 1.05) | 0.93 (0.79 to 1.11) | 0.91 (0.81 to 1.03) | 0.91 (0.83 to 1.01) | — |
τ2 | 0 | 0 | 0 | 0 | — |
First centile | 0.54 | 0.69 | 0.7 | 0.68 | 0.66 |
99th centile | 1.81 | 1.61 | 1.27 | 1.25 | 1.55 |
Median | 0.85 | 0.94 | 0.91 | 0.92 | 0.91 |
Interquartile range | 0.11 | 0.08 | 0.07 | 0.03 | 0.07 |
CI=confidence interval; HbA1c=serum glycated haemoglobin (HbA1c), expressed as a percentage.