Table 3

Dose, duration, and cost of antibiotics recently approved by US Food and Drug Administration (2016-19) and comparator regimens

Recently approved antibioticComparatorCost factor
Drug (brand name)DoseCost
(WAC, $)
DrugDoseCost range
(WAC, $)
Pretomanid
(Pretomanid)
200 mg daily for 26 weeks plus linezolid 1200 mg daily orally
and bedaquiline 400 mg daily orally for 2 weeks then 200 mg 3 times a week for 24 weeks
36 399Isoniazid, rifampin, pyrazinamide, ethambutolIntensive phase: 300 mg isoniazid, 600 mg rifampin, 1500 mg pyrazinamide, and 1200 ethambutol daily for 8 weeks.
Continuation phase: 300 mg isoniazid and 600 mg rifampin daily for 18 weeks
138026.37
Imipenem-cilastatin-relebactam (Recarbrio)1.25 g intravenously over 30 min, every 6 hours, for 4-14 days4280-14 980Imipenem-cilastatin500 mg intravenously four times a day for 4-14 days104-36441.15
Imipenem-cilastatin and
colistimethate sodium
Cilastatin and
colistimethate sodium
(300 mg) ×1 followed by 300 mg
cilastatin and
colistimethate sodium
every 12 hours and 500 mg imipenem intravenously four times a day for 4-14 days
536-17567.99-8.53
Lefamulin (Xenleta)150 mg every 12 hours intravenously for 5-7 days or 600 mg tablets every 12 hours for 5 daysIntravenously: 1025-1435. Orally: 1375Moxifloxacin(For CABP) 400 mg moxifloxacin orally or intravenously daily for 7-14 daysIntravenously: 315-630. Orally: 21-41Intravenously: 3.25-2.28
Orally: 66.81-33.41
Rifamycin (Aemcolo)388 mg every 12 hours for 3 days176Ciprofloxacin(For Traveller’s diarrhoea) 500 mg orally every 12 hours for 5-7 days2-392.65-66.18
Omadacycline (Nuzyra)Loading: 200 mg intravenously over 60 min or 100 mg intravenously over 30 min, twice on day 1, then 100 mg intravenously daily or 300 mg tablets daily. Total 7-14 days(All Indications, intravenously)
2760-5175
ABSSSI: Linezolid
CABP: Moxifloxacin
(ABSSSI, Linezolid) 600 mg intravenously or tablets twice daily for 10-14 days
(CABP, Moxifloxacin) 400 mg moxifloxacin orally or intravenously daily for 7-14 days
(ABSSSI, Linezolid)
intravenously: 720-1440. Orally: 69-137.
(CABP, Moxifloxacin)
intravenously: 315-630. Orally: 21-41
ABSSS:
Omadacycline intravenously, linezolid intravenously
=3.83-3.59.
Omadacycline intravenously, linezolid orally
=40.23-37.72.
CABP:
Omadacycline intravenously, moxifloxacin intravenously
=8.76-8.21.
Omacadycline intravenously, moxifloxacin orally
=134.11-125.73
Eravacycline (Xerava)1 mg/kg intravenously twice daily for 4-14 days588-2058Ertapenem1.0 g intravenously daily for 4-14 days400-14001.47
Meropenem1.0 g intravenously three times a day for 4-14 days85-1496.89-13.78
Plazomicin (Zemdri)15 mg/kg intravenously daily for 4-7 days283-496Meropenem1 g intravenously three times a day for 4-7 days85-1493.32
Delafloxacin (Baxdela)300 mg intravenously over 60 min twice daily for 5-14 days or 450 mg tablet twice daily for 5-14 daysIntravenously: 1325-3710. Orally: 744-2083Vancomycin and aztreonam15 mg/kg intravenously vancomycin and 2 g intravenously aztreonam twice daily for 5-14 days884-2474Delafloxacin intravenously
1.50-1.10.
Delafloxacin orally 0.84
Secnidazole (Solosec)2 g of granules once orally282Metronidazole(Bacterial vaginosis) 750 mg orally daily for 7 days648.00
Meropenem-vaborbactam Vabomere)4 g intravenously three times a day for up to 14 days29 938Piperacillin-tazobactam4 g/0.5 g intravenously three times a day for up to 10 days75439.72
Ozenoxacin (Xepi)Apply thin layer to affected area twice daily for up to 5 days (dose unspecified)297
(one 30 g tube ozenoxacin)
RetapamulinApply thin layer to the affected area twice a day for 5 days (dose unspecified)6230.48
Bezlotoxumab (Zinplava)One time intravenously 10 mg/kg2850
(for patient weighing 75 kg)
None available---
Amikacin lipsosome inhalation suspension (Arikayce)Daily oral inhalation of one 590 mg/8.4 mL vial, for indefinite use12 380
(28 day supply)
1 61 394-2 15 192
(8-16 months)
Rifampin, ethambutol, and azithromycinAzithromycin (500 mg), rifampin (600 mg), and ethambutol (25 mg/kg) three times a week for 8-16 months111
(28 day supply)
1438-1918
(8-16 months)
(28 day supply)
111.90.
(8-16 months)
112.21
Cefiderocol (Fetroja)2 g intravenously three times a day for 7-14 days7700-15 400Imipenem/cilastatinImipenem/cilastatin (1 g:1 g) intravenously three times a day for 7-14 days397-79419.6-19.4
Omeprazole magnesium-amoxicillin-rifabutin (Talicia)Four capsules three times a day for 14 days669Amoxicillin and
omeprazole
1000 mg amoxicillin and 10 mg omeprazole three times a day for 14 days977.21
  • $1 (£0.81; €0.95).