Table 2

Multivariable associations of genetically proxied metabolic and lifestyle factors with hepatic fat

Exposure	Adjustment	Without adjustment		With adjustment
Exposure	Adjustment	Beta (95% CI)	P value	Beta (95% CI)	P value
Waist-to-hip ratio	Body mass index	0.51 (0.46 to 0.57)	<0.001	0.49 (0.42 to 0.55)	<0.001
Type 2 diabetes	Body mass index	0.15 (0.12 to 0.19)	<0.001	0.14 (0.11 to 0.17)	<0.001
Systolic blood pressure	Body mass index	0.10 (0.03 to 0.16)	0.005	0.10 (0.04 to 0.15)	0.001
HDL cholesterol	Body mass index	−0.13 (−0.19 to −0.07)	<0.001	−0.11 (−0.16 to −0.06)	<0.001
LDL cholesterol	Body mass index	−0.11 (−0.2 to −0.02)	0.019	−0.11 (−0.18 to −0.04)	0.002
Triglycerides	Body mass index	0.15 (0.09 to 0.22)	<0.001	0.14 (0.08 to 0.21)	<0.001
HDL cholesterol	LDL cholesterol and triglycerides	−0.13 (−0.19 to −0.07)	<0.001	−0.11 (−0.18 to −0.04)	0.004
LDL cholesterol	HDL cholesterol and triglycerides	−0.11 (−0.20 to −0.02)	0.019	−0.13 (−0.20 to −0.06)	0.001
Triglycerides	LDL and HDL cholesterol	0.15 (0.09 to 0.22)	<0.001	0.16 (0.07 to 0.24)	0.001
Smoking initiation	Alcohol drinking	0.13 (0.07 to 0.18)	<0.001	0.09 (0.02 to 0.15)	0.009
Alcohol drinking	Smoking initiation	0.33 (0.08 to 0.58)	0.010	0.18 (0.01 to 0.35)	0.036
Alcohol drinking (without ADH1B)	Smoking initiation	0.15 (−0.12 to 0.42)	0.281	−0.04 (−0.24 to 0.15)	0.659

The unit for liver fat was standard deviation of liver fat percentage. HDL=high density lipoprotein; LDL=low density lipoprotein.