Exertional heat stroke, the third leading cause of mortality in athletes during physical activity,
is the most severe manifestation of exertional heat illnesses. Exertional heat stroke is …

New Findings What is the topic of this review? Whether there are sex differences in
exertional heat stroke. What advances does it highlight? This review utilizes a translational …

Key points Exposure to exertional heat stroke (EHS) has been linked to increased long‐term
decrements of health. Epigenetic reprogramming is involved in the response to heat …

Key points Exposure to exertional heat stroke (EHS) is associated with increased risk of long‐
term cardiovascular disorders in humans. We demonstrate that in female mice, severe EHS …

With increasing participation of females in endurance athletics and active military service, it
is important to determine if there are inherent sex-dependent susceptibilities to exertional …

Female mice have a greater capacity for exercising in the heat than male mice, reaching
greater power output and longer times of heat exposure before succumbing to exertional …

Skeletal muscles secrete a wide variety of immunologically active cytokines, but the
functional significance of this response to in vivo innate immunity is not understood. We …

New Findings What is the central question of this study? Exertional heat stroke is
accompanied by a marked inflammatory response. In this study, we explored the time course …

Sepsis continues to be a major challenge for modern medicine. Several preclinical models
were developed to study sepsis and each has strengths and weaknesses. The cecal slurry …

Introduction The capability of male mice to exercise in hot environments without succumbing
to exertional heat stroke (EHS) is markedly blunted compared to females. Epidemiological …