User profiles for "author:Rainer Malik"
Rainer MalikResearch Associate Computational Biology, LMU Munich Verified email at med.uni-muenchen.de Cited by 17879 |
Analysis of shared heritability in common disorders of the brain
Brainstorm Consortium, V Anttila, B Bulik-Sullivan… - Science, 2018 - science.org
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants
Background and Purpose—Ischemic stroke (IS) and coronary artery disease (CAD) share
several risk factors and each has a substantial heritability. We conducted a genome-wide …
several risk factors and each has a substantial heritability. We conducted a genome-wide …
Genetically determined levels of circulating cytokines and risk of stroke: role of monocyte chemoattractant protein-1
Background: Cytokines and growth factors have been implicated in the initiation and
propagation of vascular disease. Observational studies have shown associations of their …
propagation of vascular disease. Observational studies have shown associations of their …
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
Migraine is a debilitating neurological disorder affecting around one in seven people
worldwide, but its molecular mechanisms remain poorly understood. There is some debate …
worldwide, but its molecular mechanisms remain poorly understood. There is some debate …
[HTML][HTML] Stroke genetics informs drug discovery and risk prediction across ancestries
Previous genome-wide association studies (GWASs) of stroke—the second leading cause of
death worldwide—were conducted predominantly in populations of European ancestry …
death worldwide—were conducted predominantly in populations of European ancestry …
Multi-ethnic genome-wide association study for atrial fibrillation
Atrial fibrillation (AF) affects more than 33 million individuals worldwide and has a complex
heritability. We conducted the largest meta-analysis of genome-wide association studies …
heritability. We conducted the largest meta-analysis of genome-wide association studies …
[HTML][HTML] Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies
M Traylor, M Farrall, EG Holliday, C Sudlow… - The Lancet …, 2012 - thelancet.com
Background Various genome-wide association studies (GWAS) have been done in
ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have …
ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have …
Genome-wide meta-analysis identifies new susceptibility loci for migraine
Migraine is the most common brain disorder, affecting approximately 14% of the adult
population, but its molecular mechanisms are poorly understood. We report the results of a …
population, but its molecular mechanisms are poorly understood. We report the results of a …
Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations
Background and Purpose—The contribution of genetics to stroke risk, and whether this
differs for different stroke subtypes, remainsuncertain. Genomewide complex trait analysis …
differs for different stroke subtypes, remainsuncertain. Genomewide complex trait analysis …