User profiles for "author:Rainer Malik"

Rainer Malik

Research Associate Computational Biology, LMU Munich
Verified email at med.uni-muenchen.de
Cited by 17879

Analysis of shared heritability in common disorders of the brain

Brainstorm Consortium, V Anttila, B Bulik-Sullivan… - Science, 2018 - science.org
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …

Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants

M Dichgans, R Malik, IR König, J Rosand, R Clarke… - Stroke, 2014 - Am Heart Assoc
Background and Purpose—Ischemic stroke (IS) and coronary artery disease (CAD) share
several risk factors and each has a substantial heritability. We conducted a genome-wide …

Genetically determined levels of circulating cytokines and risk of stroke: role of monocyte chemoattractant protein-1

MK Georgakis, D Gill, K Rannikmäe, M Traylor… - Circulation, 2019 - Am Heart Assoc
Background: Cytokines and growth factors have been implicated in the initiation and
propagation of vascular disease. Observational studies have shown associations of their …

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

R Malik, G Chauhan, M Traylor, M Sargurupremraj… - Nature …, 2018 - nature.com
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

P Gormley, V Anttila, BS Winsvold, P Palta, T Esko… - Nature …, 2016 - nature.com
Migraine is a debilitating neurological disorder affecting around one in seven people
worldwide, but its molecular mechanisms remain poorly understood. There is some debate …

[HTML][HTML] Stroke genetics informs drug discovery and risk prediction across ancestries

A Mishra, R Malik, T Hachiya, T Jürgenson, S Namba… - Nature, 2022 - nature.com
Previous genome-wide association studies (GWASs) of stroke—the second leading cause of
death worldwide—were conducted predominantly in populations of European ancestry …

Multi-ethnic genome-wide association study for atrial fibrillation

C Roselli, MD Chaffin, LC Weng, S Aeschbacher… - Nature …, 2018 - nature.com
Atrial fibrillation (AF) affects more than 33 million individuals worldwide and has a complex
heritability. We conducted the largest meta-analysis of genome-wide association studies …

[HTML][HTML] Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies

M Traylor, M Farrall, EG Holliday, C Sudlow… - The Lancet …, 2012 - thelancet.com
Background Various genome-wide association studies (GWAS) have been done in
ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have …

Genome-wide meta-analysis identifies new susceptibility loci for migraine

V Anttila, BS Winsvold, P Gormley, T Kurth, F Bettella… - Nature …, 2013 - nature.com
Migraine is the most common brain disorder, affecting approximately 14% of the adult
population, but its molecular mechanisms are poorly understood. We report the results of a …

Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations

S Bevan, M Traylor, P Adib-Samii, R Malik, NLM Paul… - Stroke, 2012 - Am Heart Assoc
Background and Purpose—The contribution of genetics to stroke risk, and whether this
differs for different stroke subtypes, remainsuncertain. Genomewide complex trait analysis …